Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting

US7887833B2 · kind B2 · utility

Assignee

• BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY · IL

Inventors

• Eliahu Heldman · Rehovot, IL
• Charles Linder · Rehovot, IL
• Sarina Grinberg · Meitar, IL
• Victoria Kolot · Beer Sheva, IL
• Eleonora SHAUBI · Beer Sheva, IL

Key dates

• Filing date: Dec 4, 2002
• Grant date: Feb 15, 2011
• Expiry date: May 14, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.