HCV non-structural polypeptide

US7888004B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Doris Coit · Petaluma, US
• Angelica Medina-Selby · San Francisco, US
• Mark J. Selby · San Francisco, US
• Michael Houghton · Berkeley, US

Key dates

• Filing date: Oct 3, 2008
• Grant date: Feb 15, 2011
• Expiry date: Oct 3, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/24222
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.