Method for detecting a target using enzyme directed deposition of elemental metal
US7888060B2 · kind B2 · utility
13Cited by
13References
18Claims
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Key dates
| Filing date | Mar 4, 2008 |
| Grant date | Feb 15, 2011 |
| Priority date | — |
| Expiry date | Oct 2, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/581
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed embodiments concern site-specific, enzymatic-directed deposition of elemental metal for in-situ analysis. Enzyme substrates are contacted with metal ions and subsequently direct the deposition of elemental metals. Sensitive and selective detection of target molecules, such as biomarkers in various biological samples, can be obtained using various methods, such as in-situ chromogenic immunohistochemical (IHC) detection with bright field light microscopy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.