Mitoquinone derivatives used as mitochondrially targeted antioxidants
US7888334B2 · kind B2 · utility
4Cited by
9References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2004 |
| Grant date | Feb 15, 2011 |
| Priority date | — |
| Expiry date | Mar 19, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5442
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to methods to screen for, identify, select and synthesise amphiphilic mitochondrially targeted antioxidant compounds, and compositions, dosage forms and methods reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.