Pregnane steroids and their use in the treatment of CNS disorders

US7888340B2 · kind B2 · utility

Assignee

• UMECRINE AB · SE

Inventors

• Torbjörn Bäckström · Umeå, SE
• Per Lundgren · Väröbacka, SE
• Ming Wang · Montgomery, US
• Inga-Maj Johansson · Hagfors, SE

Key dates

• Filing date: Dec 20, 2002
• Grant date: Feb 15, 2011
• Expiry date: Dec 30, 2025

Classification

• Technology area (CPC —): General

Abstract

Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.