Patent · US Active

Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase

US7888343B2 · kind B2 · utility

1Cited by

4References

8Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Karl Schoenafinger · Alzenau, DE
Gerhard Jaehne · Frankfurt, DE
Elisabeth Defossa · Idstein, DE
Lothar Schwink · Stadtallendorf, DE
Holger Wagner · Mettenberg, DE
Christian Buning · Frankfurt am Main, DE
Georg Tschank · Frankfurt am Main, DE
Ulrich Werner · Frankfurt am Main, DE

Key dates

Filing date	Jan 18, 2007
Grant date	Feb 15, 2011
Priority date	—
Expiry date	Dec 27, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I:wherein the various R groups are defined herein. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds and methods for the treatment of metabolic disorders such as type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerosis diseases and the like through the administration of said compositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.