Heterocyclic sulfonamides as modulators of cardiac sarcomeres

US7888373B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Bradley P. Morgan · Moraga, US
• Fady Malik · Burlingame, US
• Erica Anne Kraynack · South San Francisco, US
• Alexander Ramon Muci · San Francisco, US
• Xiangping Qian · Foster City, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Sep 3, 2009
• Grant date: Feb 15, 2011
• Expiry date: Sep 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Certain substituted sulfonamide derivatives of Formula (I) selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.