Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof

US7888381B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jingwu Duan · Yardley, US
• Zhonghui Lu · King of Prussia, US
• David S. Weinstein · Plainsboro, US
• Bin Jiang · Norristown, US

Key dates

• Filing date: Jun 13, 2006
• Grant date: Feb 15, 2011
• Expiry date: Mar 6, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I)or an enantiomer, a diastereomer, a pharmaceutically acceptable salt, or hydrate thereof, where J is selected from NR1 or C(R4)(R4a); K is selected from NR2 or C(R5)(R5a); L is selected from NR3 or C(R6)(R6a); and A, X, Y, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R8, R10, R11, and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.