Method of preparing esomeprazole and salts thereof
US7888511B2 · kind B2 · utility
2Cited by
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14Claims
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Key dates
| Filing date | Jul 11, 2006 |
| Grant date | Feb 15, 2011 |
| Priority date | — |
| Expiry date | Feb 26, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P1/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(−)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(−)-binol, and removing the (S)-(−)-binol moiety from the crystallized inclusion complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.