Flow-through apparatus for microscopic investigation of dissolution of pharmaceutical solids
US7892492B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 7, 2006 |
| Grant date | Feb 22, 2011 |
| Priority date | — |
| Expiry date | Nov 30, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/0245
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure is directed to an apparatus and method for studying dissolution of a compact sample. The compact sample is typically a pharmaceutical drug sample. A flow-through apparatus includes a frame defining a flow-through channel, a removable insert having a drug sample, the insert positioned within the frame such that a fluid interacts with the sample when the fluid passes through the flow channel. The frame has an opening on the top side to allow a glass plate, typically a microscope cover slip to be positioned within the frame and allow viewing of the fluid flow and interaction with the drug sample. The hydrodynamics of the fluid flow are either known or computed. Thus, dissolution can be studied and observed in view of hydrodynamic characteristics. Typically, only a small amount of sample is necessary for a study. The flow-through apparatus is designed to fit on a microscopy stage and allow visual observation of the fluid/sample interaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.