Contrast agents

US7892522B2 · kind B2 · utility

Assignee

• GE HEALTHCARE AS · NO

Inventors

• David Callum Johnson · Schreiber, CA
• Jonny Østensen · Oslo, NO
• Morten Eriksen · Oslo, NO
• Audun Tornes · Oslo, NO
• Sigmund Frigstad · Trondheim, NO
• Harald Dugstad · Oslo, NO
• Jo Klaveness · Oslo, NO
• Pal Rongved · Oslo, NO
• Roald Skurtveit · Oslo, NO
• Jorunn Brænden · Oslo, NO

Key dates

• Filing date: Sep 13, 2001
• Grant date: Feb 22, 2011
• Expiry date: Sep 3, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/223
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.