Humanized antibodies that sequester amyloid beta peptide

US7892545B2 · kind B2 · utility

Assignees

• ELI LILLY AND COMPANY · US
• Washington University · US

Inventors

• David Holtzman · Chesterfield, US
• Ronald DeMattos · Noblesville, US
• Kelly R. Bales · Indianapolis, US
• Steven M. Paul · Carmel, US
• Naoya Tsurushita · Palo Alto, US
• Maximiliano Vasquez · Palo Alto, US

Key dates

• Filing date: Feb 8, 2008
• Grant date: Feb 22, 2011
• Expiry date: Feb 5, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.