Magnetic rotation to improve signal-over-background in biosensing
US7892817B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 2005 |
| Grant date | Feb 22, 2011 |
| Priority date | — |
| Expiry date | Feb 11, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/745
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and a device are provided for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle is attached to the surface. The method and device may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor combines in one sensor the detection of magnetic particles or labels and determination of the binding quality and the properties of magnetic particles or labels which are bound to the surface of another entity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.