Procedure for the determination of the activity of the protease which activates factor VII from protein solutions

US7892842B2 · kind B2 · utility

Assignee

• CSL Behring AG · DE

Inventors

• Juergen Roemisch · Marburg, DE
• Annette Feussner · Marburg, DE
• Hans-Arnold Stoehr · Wetter, DE

Key dates

• Filing date: Jun 6, 2008
• Grant date: Feb 22, 2011
• Expiry date: Dec 23, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/811
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present application relates to procedures for the determination of the activity of the protease which activates factor VII, also known as factor VII activating protease or FSAP. The application also relates to a method of detecting whether an individual has increased or lowered activity in the protease which activates factor VII compared to at least one standard sample, wherein the increased or lowered activity indicates an increased risk for disease or cardiovascular complications.