Method for producing yeast expressed HPV types 6 and 16 capsid proteins

US7897155B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Daniela Tornese Buonamassa · Siena, IT
• Catherine Greer · Oakland, US
• Cesira Galeotti · Poggibonsi, IT
• Giuliano Bensi · Siena, IT
• Roberto Petracca · Siena, IT

Key dates

• Filing date: Dec 11, 2008
• Grant date: Mar 1, 2011
• Expiry date: Dec 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/108
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.