Methods of diagnosing Alzheimer's disease

US7897361B2 · kind B2 · utility

Inventors

• Jules Westbrook · Dublin, IE
• Helen Byers · Cobham, GB
• Malcolm Ward · Cobham, GB
• Simon Lovestone · London, GB
• Abdul Hye · London, GB
• Stephen Lynham · London, GB
• Richard Joubert · Niedernhausen, DE
• Petra Prefot · Wiesbaden, DE
• Karsten Kuhn · Dortmund, DE
• Christian Andrew Baumann · Exton, US
• Juergen Schaefer · Lauterbach, DE
• Thorsten Prinz · Hofheim, DE
• Stefan Kienle · Frankfurt, DE

Key dates

• Filing date: Sep 29, 2005
• Grant date: Mar 1, 2011
• Expiry date: Sep 29, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.