Fungal cell wall synthesis gene
US7897387B2 · kind B2 · utility
0Cited by
9References
2Claims
0Family size
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Key dates
| Filing date | Apr 1, 2008 |
| Grant date | Mar 1, 2011 |
| Priority date | — |
| Expiry date | Jul 30, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/911
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.