Conjugates of defined stoichiometry

US7897404B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Eva Hoess · Starnberg, DE
• Herbert Andres · Penzberg, DE
• Frederic Donie · Penzberg, DE
• Rudolf Vogel · Salzgitter, DE
• Hans-Peter Josel · Weilheim, DE
• Rupert Hermann · Weilheim, DE
• Herbert von der Eltz · Spaichingen, DE

Key dates

• Filing date: Aug 26, 2001
• Grant date: Mar 1, 2011
• Expiry date: Aug 26, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/962
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomolecule-linker product of uniform stoichiometry in a pre-selected amount.