Patent · US Active

Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections

US7901687B2 · kind B2 · utility

0Cited by

1References

4Claims

0Family size

Assignees

ETH ZURICH · CH
Schweizerisches Tropeninstitut · CH

Inventors

Daniel B. Werz · Oebisfelde, DE
Peter H. Seeberger · Potsdam, DE
Marco Tamborrini · Basel, CH
Gerd Pluschke · Annaberg-Buchholz, DE

Key dates

Filing date	Apr 27, 2007
Grant date	Mar 8, 2011
Priority date	—
Expiry date	Apr 27, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/6081
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.