Use of AIM3 acting as a tumor suppressor
US7902165B2 · kind B2 · utility
86Cited by
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4Claims
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Key dates
| Filing date | Sep 24, 2007 |
| Grant date | Mar 8, 2011 |
| Priority date | — |
| Expiry date | Sep 24, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/205
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.