Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof

US7902217B2 · kind B2 · utility

Assignee

• Memory Pharmaceuticals Corporation · US

Inventors

• Wenge Xie · Mahwah, US
• Brian Herbert · Stockholm, US
• Jianguo Ma · Natick, US
• Truc Minh Nguyen · New York, US
• Richard Schumacher · Rochester, US
• Carla Gauss · New York, US
• Ashok Tehim · Ridgewood, US

Key dates

• Filing date: Nov 18, 2008
• Grant date: Mar 8, 2011
• Expiry date: Nov 18, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.