Isolated nucleic acid duplex for reducing huntington gene expression
US7902352B2 · kind B2 · utility
20Cited by
55References
23Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 9, 2006 |
| Grant date | Mar 8, 2011 |
| Priority date | — |
| Expiry date | Feb 28, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14171
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease by reducing HD mRNA without causing death, locomotor impairment or cellular alterations of the Macaca mulatta and Homo sapiens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.