Porous photonic crystal with light scattering domains and methods of synthesis and use thereof

US7903239B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael J. Sailor · Village of La Jolla, US
• Michael P. Schwartz · Madison, US
• Sara Alvarez · Oceanside, US
• Sangeeta N. Bhatia · Lexington, US
• Austin M. Derfus · San Diego, US
• Benjamin Migliori · Village of La Jolla, US
• Lin Chao · Del Mar, US
• Yang Li · Santa Clara, US
• Rebecca Campbell · Village of La Jolla, US
• Jason Dorvee · Ithaca, US
• Ulla Camilla Rang · Del Mar, US

Key dates

• Filing date: Oct 19, 2005
• Grant date: Mar 8, 2011
• Expiry date: Sep 1, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/54373
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.