Patent · US Active

Chimeric human sweet-umami and umami-sweet taste receptors

US7906627B2 · kind B2 · utility

37Cited by

0References

27Claims

0Family size

Assignee

SENOMYX, INC. · US

Inventors

Xiaodong Li · Bellevue, US
Feng Zhang · Tianjin, CN
Hong Xu · San Diego, US
Qing Li · San Diego, US

Key dates

Filing date	Oct 19, 2006
Grant date	Mar 15, 2011
Priority date	—
Expiry date	Dec 24, 2027

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/10
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.