Biocompatible titanium alloys
US7910221B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 2007 |
| Grant date | Mar 22, 2011 |
| Priority date | — |
| Expiry date | Apr 30, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2953
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods and compositions are disclosed for coating a biocompatible medical implant with a surface layer having antioxidant activity. In various embodiments, a surface layer described herein destroys the oxidative activity of a reactive oxygen species (ROS) upon contact. An ROS can be, for example, an ROS generated by neutrophils in vivo. In various embodiments, a surface layer comprises a titanium oxide layer that can comprise a rutile, an anatase or a perovskite crystal structure, and can include defects comprising Ti(III). In some embodiments, the oxide layer can further comprise a dopant such as niobium. In some embodiments, methods for forming a surface layer on a biocompatible medical implant having antioxidant activity are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.