Methods compositions and compound assays for inhibiting amyloid-beta protein production
US7910320B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Aug 13, 2008 |
| Grant date | Mar 22, 2011 |
| Priority date | — |
| Expiry date | Nov 21, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.