Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system
US7910363B1 · kind B1 · utility
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32Claims
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Key dates
| Filing date | May 2, 2008 |
| Grant date | Mar 22, 2011 |
| Priority date | — |
| Expiry date | May 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/87
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Polyamine cationic lipids have been synthesized that have the ability to be transported into cells having an active polyamine transport system. Accordingly, these lipids may be conjugated with various agents and, thereby, act as vectors for transporting the agent into the cell aided by the cell's own polyamine transport system. A method of delivering an agent into a cell includes associating the agent with a polyamine cationic lipid selected from compounds 25, 26, 27, 28, their pharmaceutically acceptable salts and combinations thereof and contacting the cell therewith.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.