Conformationally constrained parthyroid hormone (PTH) analogs
US7910544B2 · kind B2 · utility
4Cited by
92References
39Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 16, 2004 |
| Grant date | Mar 22, 2011 |
| Priority date | — |
| Expiry date | Feb 1, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane (“J”) domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.