C-Met receptor regulation by angiotensin IV (AT4 ) receptor ligands

US7910555B2 · kind B2 · utility

Assignee

• Washington State University Research Foundation · US

Inventors

• Joseph W. Harding · Pullman, US
• John W. Wright · Los Altos, US
• Patrick D. Elias · Pullman, US
• Brent J. Yamamoto · Pullman, US

Key dates

• Filing date: Jul 6, 2007
• Grant date: Mar 22, 2011
• Expiry date: Dec 1, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/93
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The cell surface c-Met receptor, through which hepatocyte growth factor (HGF) signals are mediated, has now been identified as the Angiotensin-IV receptor (AT(4)R) in processes that include HGF-regulated cell motility, angiogenesis cancer metastasis and others. Disclosed are angiotensin-like factor compositions and methods for using them to diagnose, prevent and/or treat conditions associated with c-Met dysregulation, including altering hepatocyte growth factor activity or c-Met receptor activity by administering an angiotensin-like factor that specifically binds to a cell surface c-Met receptor.