Inhibitors of integrin alpha2beta1 with modified urea moiety

US7910609B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• William F. DeGrado · Media, US
• Seth Elliott Snyder · The Bronx, US
• Meredith W. Miller · Philadelphia, US
• Sandeep Basra · Munich, DE
• Joel Bennett · Greensboro, US
• Sungwook Choi · Paju-si, KR

Key dates

• Filing date: Sep 24, 2008
• Grant date: Mar 22, 2011
• Expiry date: Sep 24, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06165
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.