Patent · US Active

Small molecule antagonists of XIAP family proteins

US7910621B2 · kind B2 · utility

2Cited by

0References

22Claims

0Family size

Assignee

THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

Jianyong Chen · Tangxia, CN
Zaneta Nikolovska-Coleska · Ann Arbor, US
Dajun Yang · Suzhou, CN
Shaomeng Wang · Saline, US
Haiying Sun · Ann Arbor, US
Liang Xu · Ann Arbor, US
Zengjian Hu · Gaithersburg, US

Key dates

Filing date	Mar 22, 2005
Grant date	Mar 22, 2011
Priority date	—
Expiry date	Sep 11, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D311/30
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.