Stabiliser for radiopharmaceuticals
US7914768B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 18, 2001 |
| Grant date | Mar 29, 2011 |
| Priority date | — |
| Expiry date | Jan 1, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stabilized radiopharmaceutical composition, a kit including same, and a method for making same, where the radiopharmaceutical is (i) susceptible to either reductive degradation or radiolysis and which includes a metal complex of a radionuclide with a ligand, (ii) a first stabilizer for the radiopharmaceutical which is an amino-substituted aromatic carboxylic acid or a salt, ester or amide thereof, and (iii) a second stabilizer for the radiopharmaceutical which is a diphosphonic acid or salt thereof. The first and second stabilizers are present in an amount effective to stabilize the radiopharmaceutical, and the radiopharmaceutical is not a metal complex of the diphosphonic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.