Activation and inhibition of the immune system

US7915009B2 · kind B2 · utility

Assignee

• The Mathilda and Terence Kennedy Institute of Rheumatology Trust · GB

Inventors

• Brian Maurice John Foxwell · London, GB
• Marc Feldmann · London, GB

Key dates

• Filing date: Dec 22, 2000
• Grant date: Mar 29, 2011
• Expiry date: Aug 27, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Activation of the immune response by NF-kB inducers, induction of an anergic response by NF-kB inhibitors and the inhibition and activation of immune response by the administration of an activator or inhibitor of NF-kB is disclosed. Examples of NF-kB inhibitors include IkBα, PSI, a nucleotide sequence encoding IkBα anti-sense nucleic acid encoding an NF-kB sequence, such as Rel B, and anti-NF-kB antibodies. Examples of NF-kB inducers include NIK, MEKK, IKK2, TFRRF2, and Rel B. Also disclosed are vectors encoding inducers and inhibitors of NF-kB, for example adenoviral vectors.