Methods for construction and screening of libraries of chemokine variants
US7915221B2 · kind B2 · utility
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Key dates
| Filing date | Apr 2, 2007 |
| Grant date | Mar 29, 2011 |
| Priority date | — |
| Expiry date | Apr 8, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.