Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
US7915241B2 · kind B2 · utility
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Key dates
| Filing date | Oct 8, 2004 |
| Grant date | Mar 29, 2011 |
| Priority date | — |
| Expiry date | Aug 20, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula 1 having a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR1 group, where R1, R2 and R3 may be the same or different and represent groups suitable for hydroxyl protection, and R4 is a C1-6 alkyl chain or a C1-6 cykloalkyl group, optionally substituted with C1-3 alkyl groups, especially for calcipotriol.The invention also provides new intermediates and non-racemic compounds being valuable synthones for the synthesis of pharmacologically active substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.