Crystal forms of pyrrolylheptanoic acid derivatives
US7915302B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Mar 3, 2008 |
| Grant date | Mar 29, 2011 |
| Priority date | — |
| Expiry date | Mar 3, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel crystalline forms D1 and D2 of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder diffraction peaks described in FIGS. 1 and 3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.