Amino methylated 2-pyridinones

US7915417B2 · kind B2 · utility

Assignee

• Washington University · US

Inventors

• Scott Hultgren · Ballwin, US
• Jerome S. Pinkner · Chesterfield, US
• Fredrik Almqvist · Umeå, SE
• Nils Pemberton · Umeå, SE
• Veronica Aberg · Umeå, SE
• Andreas Larsson · Umeå, SE

Key dates

• Filing date: Aug 11, 2008
• Grant date: Mar 29, 2011
• Expiry date: Aug 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit adherence of bacteria to a host cell.