PH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy

US7919076B2 · kind B2 · utility

Assignee

• Zentiva K.S. · CZ

Inventors

• Karel Ulbrich · Praha, CZ
• Tomas Etrych · Klínec, CZ
• Blanka Rihova · Praha, CZ
• Marketa Jelinkova · Praha, CZ
• Marek Kovar · Praha, CZ

Key dates

• Filing date: Dec 20, 2002
• Grant date: Apr 5, 2011
• Expiry date: Mar 23, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides or their sodium salts.