Soluble and stabilized trimeric form of gp41 polypeptides
US7919100B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jul 29, 2004 |
| Grant date | Apr 5, 2011 |
| Priority date | — |
| Expiry date | Nov 18, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns a modified polypeptide containing at least an immunodominant region and the connecting loop between N- and C-helices of gp41 ectodomain of HIV-1, wherein the connecting loop includes at least a linker fragment having: —a size convenient for keeping the native conformation of the interaction between N- and C-helices, and —an hydrophily sufficient to provide a soluble and stable trimeric form to said modified polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.