Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof

US7919104B2 · kind B2 · utility

Assignee

• The United States of America as represtented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · US

Inventors

• Edwin W. Ades · Atlanta, US
• Jacquelyn S. Sampson · College Park, US
• Sandra Steiner · Atlanta, US
• George M. Carlone · Stone Mountain, US
• Joseph Caba · Atlanta, US
• Gowrisankar Rajam · Tucker, US

Key dates

• Filing date: Jul 29, 2005
• Grant date: Apr 5, 2011
• Expiry date: Dec 19, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. Immunogenic compositions comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier or the peptide of SEQ ID NO:2 and a pharmaceutical carrier are also provided. Methods of using the peptides and antibodies of the invention are provided.