Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles

US7919109B2 · kind B2 · utility

Assignee

• Intarcia Therapeutics, Inc. · US

Inventors

• Stephen A. Berry · Longview, US
• Pamela J. Fereira · Redwood City, US
• Houdin Dehnad · El Granada, US
• Anna Muchnik · Belmont, US

Key dates

• Filing date: Mar 11, 2008
• Grant date: Apr 5, 2011
• Expiry date: Oct 11, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.