Targeted deletions using retroelement-mediated placement of recombination sites
US7919322B2 · kind B2 · utility
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Key dates
| Filing date | Mar 29, 2006 |
| Grant date | Apr 5, 2011 |
| Priority date | — |
| Expiry date | Apr 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/70
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods, nucleic acid constructs, and kits for selectively deleting a region of a nucleic acid sequence. Specifically, it utilizes retargeting retroelements to place site-specific recombination sites at targeted locations in the nucleic acid sequence. The region between the recombination sites is then deleted using a site-specific recombination system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.