Thiadiazole modulators of PKB

US7919504B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Qingping Zeng · Thousand Oaks, US
• Chester Chenguang Yuan · Newbury Park, US
• Guomin Yao · Mililani, US
• Xianghong Wang · Dublin, US
• Seifu Tadesse · Simi Valley, US
• Andreas Reichelt · Moorpark, US
• Qingyian Liu · Camarillo, US
• Matthew Lee · Calabasas, US
• Xin Huang · Brookline, US
• Fang-Tsao Hong · Thousand Oaks, US
• Nianhe Han · Newbury Park, US
• Christopher H. Fotsch · Thousand Oaks, US
• Celia Dominguez · Los Angeles, US
• Matthew P. Bourbeau · Calabasas, US
• John Gordon Allen · Newbury Park, US

Key dates

• Filing date: Jul 15, 2008
• Grant date: Apr 5, 2011
• Expiry date: Aug 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein.The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.