Method for separating off viruses from a protein solution by means of nanofiltration

US7919592B2 · kind B2 · utility

Assignee

• ZLB Behring AG · CH

Inventors

• Thomas Lengsfeld · Marburg, DE
• Heinrich Schneider

Key dates

• Filing date: Mar 13, 2003
• Grant date: Apr 5, 2011
• Expiry date: Mar 13, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2/0017
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for separating off viruses from a protein solution by nanofiltration, comprising adding to the protein solution at least one ingredient chosen from chaotropic substances chosen from arginine, guanidine, citrulline, urea and derivatives thereof and salts thereof, and compounds chosen from polyethoxysorbitan esters and derivatives thereof, prior to the nanofiltration, in order to decrease or prevent aggregation of the protein molecules, and then filtering the solution through a filter having a pore size ranging from 15 nm to less than 35 nm.