Pyrazole compounds and uses thereof

US7919626B2 · kind B2 · utility

Assignee

• Helicon Therapeutics, Inc. · US

Inventors

• Xianbo Zhou · Dobbs Ferry, US
• Roderick E. M. Scott · New York, US
• Rusiko Bourtchouladze · New York, US
• Alan P. Kaplan · San Diego, US
• Terence P. Keenan · Cambridge, US
• Andrew J. McRiner · Melrose, US

Key dates

• Filing date: Feb 27, 2007
• Grant date: Apr 5, 2011
• Expiry date: Dec 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a compound of formula I:wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.