Transgenic pig with altered incretin function

US7919673B2 · kind B2 · utility

Assignees

• Ludwig-Maximilians-Universitat Munchen · DE
• MWM BIOMODELS GMBH · DE

Inventors

• Eckhard Wolf · Reichenbach/Oberlausitz, DE
• Simone Renner · Birkenfeld, DE
• Barbara Kessler · Birkenfeld, DE
• Rüdiger Wanke · Birkenfeld, DE
• Nadja Herbach · Birkenfeld, DE
• Alexander Pfeifer · Bonn, DE
• Andreas Hofmann · Bonn, DE

Key dates

• Filing date: Jan 4, 2009
• Grant date: Apr 5, 2011
• Expiry date: Jan 4, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/042
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.