Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
US7923247B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 17, 2008 |
| Grant date | Apr 12, 2011 |
| Priority date | — |
| Expiry date | Jan 5, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/25
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.