Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
US7923459B2 · kind B2 · utility
26Cited by
11References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 10, 2007 |
| Grant date | Apr 12, 2011 |
| Priority date | — |
| Expiry date | Sep 27, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.