Tat-based immunomodulatory compositions and methods of their discovery and use
US7927580B2 · kind B2 · utility
7Cited by
39References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 16, 2005 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Jul 7, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for identifying new immunomodulatory chemical entities (NICE) comprising reacting a candidate NICE with a Tat SH3 binding domain, identifying the bound candidate NICE and determining whether the candidate NICE induces monocytes to differentiate into dendritic cells (DC) or regulatory macrophages (AReg). In particular, the present invention relates to identifying NICE that are either immunostimulatory or immunosuppressive.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.