Detection and amplification of ligands
US7927827B2 · kind B2 · utility
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21References
10Claims
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Key dates
| Filing date | May 21, 2007 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Dec 28, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/573
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.